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Additionally, methylated quinolines such as 5-amino-1-methylquinolinium have been identified as NNMT inhibitors through ligand-based in silico methods and biological evaluations 203

Supplementary Figure S2 shows that HaCaT cells had an apparent cytotoxic effect with the treatment of 1,600 M of H 2 O 2 , while HFF-1 showed obvious cytotoxicity at 800 M of H 2 O 2 after 2 h incubation

doi: 10.1016/j.canlet.2018.02.011 6 FakhriSMoradiSZAsh-RafzadehABishayeeA

Among these compounds, colladin exhibited the most potent inhibitory activity against AChE, hCA I, and hCA II, with IC50 values of 8.25 nM, 28.90 nM, and 43.31 nM, respectively

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The authors of these studies need to repeat these results in animals before they can test if it works this way in people