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Peptides, in general, are short chains of amino acids that act as signaling molecules

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In states of obesity and aging, NNMT is often overexpressed, leading to the excessive methylation and excretion of nicotinamide

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Additionally, they can secrete VEGF-A, which is an angiogenic factor, and produce proangiogenic cytokines, such as IL-1, TNF and uPA (urokinase-type plasminogen activator) (Roy and Li, 2016)