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They comprise diverse subpopulations characterized by their ontogeny and polarization state ( During the resolution of inflammation, macrophages accumulate glutamine from the extracellular environment or through the engulfment of apoptotic cells and break it down into the TCA cycle intermediate -ketoglutarate ( Recent studies suggest that crosstalk between macrophages and other immune cells such as mast cells may affect their metabolic fates and enhance functional outcomes during immune activity

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This represents a significant consideration for healthcare providers and patients making treatment decisions

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Ongoing research endeavors are looking into the therapeutic advantages of DSIP in mitigating inflammation and oxidative stress within the brain, underscoring its potential as a valuable adjunct in the management of diverse neurological disorders