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Signaling cascades initiate
Ageing and Degenerative Disease UKM Research Group, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia
The most potent synergistic effect was observed on collagen IV, with a 25.4-fold increase in cell tests and a 2.03-fold increase in ex-vivo skin tests at a 1:9 ratio of GHK-Cu to LMW HA
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Oxalate induces type II epithelial to mesenchymal transition (EMT) in inner medullary collecting duct cells (IMCD) in vitro and stimulate the expression of osteogenic and fibrotic markers in kidney medulla in vivo
The mechanistic rationale is complementary: GHK-Cu supports collagen synthesis and extracellular matrix remodeling
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