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Design of Novel Exendin-Based Dual Glucagon-Like Peptide 1 (GLP-1)/Glucagon Receptor Agonists

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doi: 10.1016/j.cbpa.2018.12.007 57 DeKoskyS

J Org Chem 78(2):320327 Pratley RE, et al (2018) Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial Lancet Diabetes Endocrinol Ralhan K, KrishnaKumar VG, Gupta (2015) Piperazine and dbu: a safer alternative for rapid and efficient fmoc deprotection in solid phase peptide synthesis

Glucagon raises blood sugar

However, as is often the case, negative commentary appears to generate more interest, with sceptics questioning whether something as simple as a weekly injection can address a condition as complex as obesity