Cholesterol has other important roles in human metabolism
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This receptor interaction activates intracellular signaling pathways, primarily via adenylate cyclase stimulation and increased cyclic AMP (cAMP) production
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Because the peptide occurs naturally in human plasma (at roughly 200 ng/mL in young adults, declining to approximately 80 ng/mL by age 60), topical supplementation essentially restores youthful local concentrations in treated skin
This results in the recruitment of immune cells and the release of pro-inflammatory cytokines, which in turn influence keratinocyte and fibroblast activity [43, 47]