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Surfactants such as sodium lauryl sulphate can solubilise intercellular lipids, diminishing the barrier resistance of the stratum corneum and enhancing the penetration of vesicular carriers [287]

Western blotting showed that TGF-1 + IL-1 treatment time-dependently upregulated the expression of NLRP3, ASC and active caspase-1 p20 in fibroblasts, while GSDMD-NT did not change significantly (Fig

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C., Reber, T., Kr, S., & Nemutlu, E

Pharmacological characterization of a novel potent, selective, and orally active phosphodiesterase 10A inhibitor, PDM-042 [(E)-4-(2-(2-(5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazin-2-yl)vinyl)-6-(pyrrolidin-1-yl)pyrimidin-4-yl)morpholine] in rats: potential for the treatment of schizophrenia