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Additionally, these substances play a role in regulating vascular remodeling, essential for maintaining adequate blood flow to the brain and supporting neuronal function

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The cost is a real chronic-exposure burden on the myocardium, but it is small in energetic terms the entire resting myocardium consumes only about 170210 kcal/day, so a 1 bpm rise on a base of 70 represents roughly 1.4% of that, on the order of 23 kcal/day

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Harvard Medical School