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Because no long-duration human studies exist, the consequences of months or years of repeated dosing on the immune system, hormonal axes, or fibrotic tissue remodeling are simply unknown
It is important to allow adequate time at each dose level before concluding that appetite suppression is insufficient
References: Gwyer, D., Wragg, N
In adults with chronic constipation, 28 days of treatment with 1,500 mg magnesium oxide or 1,000 mg of senna (a stimulant laxative) per day significantly improved symptoms overall (68% and 69%, respectively) compared with placebo (almost 12%)
Most side effects are gastrointestinal and occur during the early weeks of treatment or when the dose is increased
Interaction of coenzyme Q10 with the intestinal drug transporter P-glycoprotein
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