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PKC isoforms localize due to compartment and signal-organizing scaffolds using receptors for activated C kinases (RACKs), A-kinase anchoring proteins (AKAPs), heat shock proteins (HSPs) as well as annexins (AnxA1, A2, A5, and A6) (Hoque et al., 2014)
Cortistatin sleep studies used intracerebroventricular administration, limiting practical applicability Anti-Inflammatory Co-Benefits Cortistatin Cortistatin has potent anti-inflammatory activity demonstrated in models of IBD, sepsis, and arthritis
[13] [15] Is it safe to use during pregnancy or breastfeeding
Ethics declarations Competing interests J
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