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Methods We searched MEDLINE (19962014), EMBase (19742014), and CENTRAL (May 2014) up to June 27, 2014 for randomized controlled trials (RCTs) comparing ALC with placebo or other active medications in diabetic and non-diabetic PNP patients that reported the change of pain using visual analogue scale (VAS)

They are sold as dietary supplements, which means they are not reviewed for safety, effectiveness, or quality the same way prescription GLP-1 treatments are

It is a microbiome-mediated GLP-1 optimisation strategy

Quick Answer: You can activate GLP-1 hormone naturally by consuming high-fibre foods, lean proteins, healthy fats, engaging in regular physical activity, maintaining adequate sleep, and supporting gut microbiome health

These differences may be associated with the fact that in these studies the PWS and the control groups were matched based on parameters of body AT including accurate parameters of fat ratio distribution [18]

doi: 10.1186/s12944-018-0939-6