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Rapid weight loss (especially with inadequate protein intake) on these drugs might accelerate muscle protein breakdown
In its first year on the market in T2DM (2022), Mounjaro brought in $483 million in global sales
Protein Becomes Your Foundation: Meeting protein goals helps prevent muscle loss, supports metabolism, and promotes satiety on fewer calories
However, a substantial body of data suggests that GIP resistance can be largely overcome by agents that lower the circulating glucose level, paving the way for the consideration of GIP as an add-on to glucose-lowering therapies, like GLP-1
Finally, NAC supports the Nrf2-dependent transcription pathway, a genetic cellular defense mechanism that upregulates the production of endogenous antioxidant enzymes, providing a robust buffer against the oxidative damage to DNA, proteins, and lipids that naturally occurs with aging and chronic illness
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