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The relevance of this observation extends to the wider family of GPCRs, with individual effects almost certainly receptor-specific, as both -arrestin-biased 54 and G protein-biased 55 ligands have proved effective for individual receptors in preclinical studies
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Mechanisms Involved in the Relationship between Vitamin D and Insulin Resistance: Impact on Clinical Practice
N Engl J Med 2015;373:11-22.ArticlePubMed 21
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