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GLP-1, or glucagon-like peptide-1, is a hormone released in the intestines in response to food intake
11 The well-known mechanism for p70S6K1 to promote survival is that p70S6K1 phosphorylates mouse double minute 2 (MDM2) leading to polyubiquitination and degradation of p53, and thus represses p53-dependent apoptosis
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For example, in a prospective study aimed at investigating the influence of GLP-1RA and DPP4 inhibitors on the development of depression in patients with newly diagnosed T2DM, participants receiving incretin-based therapies displayed marked reduction of depressive symptoms after one year, when compared to the control group
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