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Intracellular G-protein-coupled receptors, particularly the trace amine-associated receptor 1 (TAAR1), function as internal sensors of cytoplasmic catecholamines and their metabolites (Underhill et al., 2021)

Further research to evaluate the psychometric validity of the PROs is recommended to support trial endpoints and track disease severity

Long-Term Outlook and Maintenance Strategies Successfully resolving an acute injury or achieving control of chronic inflammation raises the question of long-term strategy

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