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with Arg242 and Arg257 of VP1 from neighbouring protomers in the interface conferring strong positive charge characteristics to the GSH-binding pocket and forming hydrogen bond and saltbridge contacts with the carboxy terminus of GSH (Fig

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Clinical findings might include possible pernicious anaemia or neuropathy including subacute combined degeneration of the cord

Early stromal-oriented designs often focused on matrix depletion or enzymatic loosening

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Activation of the p62-Keapl-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells