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The damage from freeze-thaw cycles comes from repeated freezing and thawing of the same solution, where ice crystals form, melt, reform, and melt again, each cycle physically stressing the peptide molecules
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Reconstituted BPC-157 should not be frozen due to freeze-thaw damage
Sherif, S., Bendas, E
The incidence of injection site reactions was 24.5% in tesamorelin-treated patients and 14.4% in placebo-treated patients during the first 26 weeks of treatment in the Phase 3 clinical trials
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