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Data suggest that despite fluctuations in carnitine concentration due to its osmolytic pressure changes, carnitine maintains its energy production capacities and often osmolytic gradients can be harnessed for energy[19]

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Therapeutic strategies targeting mitochondrial dysfunction for comorbidity intervention (Table 2) Enhancing mitochondrial energy metabolism Mitochondrial protectants Coenzyme Q10, a well-established clinical therapeutic agent, is a component of the ETC and plays a dual role in facilitating electron transfer and exerting potent antioxidant effects