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Real-world titration, persistence & body-composition research of semaglutide and [PMID: 40762026] Laboratory literature summary: Real-world titration, persistence & body-composition research of semaglutide and tirzepatide in an academic metabolic research models clinic
Ther Adv Med Oncol
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Irritation or adverse reactions Skin irritation from topical application usually responds to reducing frequency or concentration
Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)
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