4a).These metabolites are involved in one-carbon metabolism, methylation processes, and amino acid biosynthesis, suggesting coordinated alterations in pathways relevant to cellular methylation and metabolic regulation in ASD
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As PDs action, motor, somatic, arousal and cognitive symptoms are not effector specific, but are multidomain and affect the whole body, SCAN dysfunction might contribute to its pathophysiology, and therefore SCAN-specific neuromodulation might help to treat its symptoms 37,38