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The transfer of heme via an intermediate compartment would minimise the release of cytotoxic heme into the cytoplasm and facilitate the regulated movement of heme (Severance and Hamza 2009)

Brunner J, Skrabal P, Hausser H

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High-fat or WD has equivocal effects on hippocampus-based memory tasks (7784), however in tasks using amygdala-based memory task, male mice were found to have selectively impaired cued fear memory in response to diet exposure (85), consistent with our results, or finding no significant impact of WD on hippocampus-dependent memory tasks (83,84)

31 KongF.WuT.DaiJ.ZhaiZ.CaiJ.ZhuZ.et al (2023)