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However, because cytokines are locally-acting paracrine and autocrine factors, one cannot assume that a sample of cerebrospinal fluid taken during a lumbar puncture spinal tap accurately reflects the entirety of the central nervous system cerebrospinal fluid

Okudaira, H., Hongo, O., Ogita, T., Haida, M., Yamauchi, N., Miyamoto, T., Serum IgE and IgE antibody levels in patients with bronchial astma, atopic dermatitis, eosinophilic granulomas of the soft tissue (Kimuras disease) and other diseases, Ann

Its up-regulation is a part of adaptive mechanisms of the cells