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GLP-1 meds and gastrointestinal side effects: A closer look Semaglutide (Ozempic) and its siblings the GLP-1 agonists have made it into the public consciousness in a big way
Notably, GIP exerts several metabolic actions on extra-pancreatic tissues including adipose tissue, brain and bone (Fig
In RSL3-induced glioblastoma cell models, excessive activation of NF-KB represses ATF4 and SLC7A11, causing overproduction of lipid peroxidation byproducts and exacerbating ferroptosis (126)
We thank the Cleveland Clinic Cardiology Fellowship Program for providing support from the Ralph C
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Mechanistically, hepatic JNK suppresses PPAR activity via the corepressors NCoR1 and NRIP1, leading to reduced fatty acid oxidation and increased lipid synthesis (52)
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