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Effects of GLP-1 and incretin-based therapies on gastrointestinal motor function

The dose is gradually increased over 16 weeks to minimise gastrointestinal side effects and allow the body to adjust, as outlined in the MHRA/EMC Summary of Product Characteristics

In the same period, the share of adults classified as obese declined from 42.3% to 40.7%, and the share of adults in the healthy BMI range rose from 25.1% to 25.6%

Increased cellular delivery of glutathione

To resolve the current controversies regarding the use of GLP-1 RAs in treating hypertension and ischemic cardiomyopathy, large-scale clinical RCTs or real-world studies should be designed to provide more robust evidence

Possible side effects include mild nausea, headaches, or skin rashes