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The most commonly referenced community protocol is 50 mcg per day for 10 consecutive days, followed by 4 weeks off (see dosing guide)

It is worth emphasizing that the gradual approach used did not reduce weight loss or compromise glycemic efficacy, reinforcing that tolerability, not symptom intensity, should guide dose advancement ( A patient centered approach of starting low and going slow prioritizes safety and adherence, building on the principle of doing no harm

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