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Intriguingly, PC ae C34:0, C38:6, C44:6, and SM C16:1 and C18:0 significantly decreased with age (Fig 1B)

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Continuous MT-1 administration beyond 3 weeks causes receptor desensitization, where melanocytes downregulate MC1R surface expression in response to sustained agonist binding

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doi: 10.1155/2019/6879412