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However, the practical translation of such high photothermal efficiencies remains challenging due to variability in tumor NIR exposure and potential heat dissipation in vivo, which may limit uniform thermal distribution and efficacy in heterogeneous tumors

Factors affecting response include: Duration of hair loss (recent loss responds better than long-standing)

GCN2 is a kinase which senses amino acid limitation, while PERK is activated in response to ER stress 15

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