Choose 2mL (5mg/mL) if: You are starting retatrutide for the first time Your current dose is 5mg per week or lower You want maximum measurement accuracy You prefer straightforward math Choose 1mL (10mg/mL) if: Your dose is 6mg per week or higher You want smaller injection volumes You are comfortable with precise syringe measurements You have experience reconstituting peptides Some researchers start with 2mL during their initial escalation phase and switch to 1mL once they reach maintenance doses above 4mg
Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): Steinberg, W
Scientific References B vitamins and folic acid Vitamins and minerals
If you want a deeper breakdown of this pathway, our GLP-1 explainer on how semaglutide works for weight loss is a helpful next read
Based on current data, retatrutide appears to be the strongest weight loss injection studied so far
Strippoli GFM, Bonifati C, Craig M, Navaneethan SD, Craig JC (2006) Angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists for preventing the progression of diabetic kidney disease