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Hyperhomocysteinemia was also associated with both arterial and venous premature thromboembolic events in subjects less than 45 years old (D'Angelo and Selhub, 1997
The SERPINE1 gene encodes plasminogen activator inhibitor 1 (PAI-1), leading to hypofibrinolysis, and is closely associated with diabetes and IR (291, 292)
It helps to view these as a progression in medical science
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