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PEITC induced CpG demethylation in GSTP1 promoter of LNCAP cells in a concentration-dependent manner and was almost similar or higher than the commonly used DNMT inhibitor 5-Aza-2-deoxycytidine
Significant targets and the effects of PKGI in SMC are activation of myosin light chain phosphatase, inhibition of PLC, inhibition of the IP 3 receptor, inhibition of plasma membrane localized L-type Ca 2+ channels, and activation of plasma membrane localized calcium-activated K + channels (commonly called the big potassium, BK, channels)
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Exception : Antibiotics prescribed for prophylactic purposes (such as an acne treatment) may be acceptable
Specifically, fatty acid metabolism (normalized enrichment score (NES) = 1.66), oxidative phosphorylation (OxPhos
10.1038/381571a0 117
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