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TCF4 knockdown can promote ferroptosis and increase the cisplatin sensitivity of gastric cancer cells, 197 suggesting that abnormal activation of Wnt/-catenin pathway increases ferroptosis resistance in gastric cancer cells, offering a possible therapeutic strategy for enhancing chemotherapy sensitivity in patients with advanced gastric cancer

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References: Katzung BG (2021): Introduction to Autonomic Pharmacology (Chapter 6)

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Unlike some alternatives, it does not increase appetite, cortisol, or prolactin