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doi:10.1016/j.sxmr.2017.02.004PMID:28526632 [15] U.S

In a trial which enrolled patients inadequately controlled on premix insulin, bolus insulin alone, basal insulin alone, OADs alone or in any combination, insulin degludec administered once daily with the main evening meal was noninferior to insulin glargine administered once daily in reducing A1C from baseline (adjusted mean change from baseline = -1.10 and -1.18 for insulin degludec and insulin glargine, respectively