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Centella and its constituents are classified as weak contact sensitizers and some rare cases of allergic contact dermatitis exist
When researchers measured this, reflection accounted for only about 4-5% of the protection (and less than SPF 2 on its own)
Biochemical Role in Redox Research Reported preclinical work has characterized the interconversion between reduced glutathione and its oxidized disulfide form, a cycle mediated by glutathione peroxidase and restored by NADPH-dependent glutathione reductase
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doi:10.1111/j.1432-1033.1997.00273.x
In contrast, evidence from a Norwegian nested case-control study involving hospital nurses demonstrated statistically significant telomere shortening associated with long-term NS ( 6 consecutive nights, for 5 years)
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