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While BPC-157 does not develop traditional tolerance since it operates non-hormonally and does not suppress natural production, the possibility of receptor desensitization remains a theoretical concern

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This means, the presence of both mutated COMT and mutated MTHFR genes, together, may worsen the problem

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Scientific References (External Links) Nature Chemical Biology: Small molecule inhibitors of nicotinamide N-methyltransferase View Study Biochemical Pharmacology: Nicotinamide N-methyltransferase: A promising target for treating metabolic disorders View Study FASEB Journal: Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity in mice View Study Journal of Biological Chemistry: Inhibition of nicotinamide N-methyltransferase in vivo regulates cellular energy metabolism View Study