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He C, Zheng S, Luo Y, Wang B
Upon activation, the receptor triggers intracellular signaling cascades, mainly via cyclic adenosine monophosphate (cAMP) production and protein kinase A (PKA) activation
In terms of renal effects, the evidence of SGLT2is in preventing kidney failure is more abundant than for GLP-1RAs, which showed a beneficial effect on albuminuria and not on hard kidney endpoints [3, 6, 8]
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