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Data expressed as percentage change taking normoxic value as 100% and represents Mean SEM

After each increase, blood levels peak over 24 to 72 hours, when nausea and fullness are most likely to return. These effects usually ease during the four-week hold

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It is typically most pronounced during the first 1 to 2 weeks of each dose escalation and tends to improve with continued use

The results were mixed at best

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