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Insulin resistance: Growth hormone antagonizes insulin's effects
To this end, we performed a preclinical study in 18-mo-old male and female mice treated with vehicle or an IGF-1R mAb (L2-Cmu, Amgen Inc), and determined effects on aging outcomes
The branded product (Geref) was later discontinued for commercial (not safety) reasons
IGF-1 plays many important roles in the body
It facilitates the conversion of glutathione from its oxidized state back to its reduced, active form, ensuring that glutathione continues to protect against free radical damage (particularly in the part of the process involving enzyme glutathione s transferase)
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