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All preparation and handling equipment should be sterile and properly maintained to reduce the risk of contamination or compromised results

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47 During the initial phase of CR interventions, serum markers of bone turnoversuch as osteocalcin, C-terminal telopeptide of type I collagen (CTX), and N-terminal telopeptide (NTX)increase significantly, reflecting an acceleration of bone resorption

Analogamente, lo studio OASIS 1 con semaglutide orale 50 mg ha documentato eventi di questa natura, seppur a incidenze inferiori rispetto alle dosi sottocutanee pi alte (Knop et al., 2023)

The apparent permeability coefficients (P app ) were calculated as described previously [40] with the following equation: where [C] A is the concentration difference of in the acceptor compartment at 24 h, [C] D is the concentration in the donor compartment at 0 h, V A is the volume of the acceptor compartment (0.9 ml), and A is the surface area available for permeability (0.33 cm 2 )

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