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Due to this feature, iron accumulation can foster the production of lipid radicals through a Fenton-like reaction and the progression to lipid peroxidation [74]

Autophagy provides metabolic substrates through recycling pathways, helping cancer cells survive under nutrient deprivation, hypoxia, immune stress, and therapeutic challenge

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The maintenance of thioredoxin in a reduced form by TXNRDs is important for regulating cell growth and survival

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Thanks to these properties, niacinamide is effective in combating acne and inflammation caused by clogged pores and impurities