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It turns out the GLP-1 mechanism is at play too: Berberine GLP-1 agonist The research community has known since 2009 -- and perhaps longer -- that berberine is a GLP-1 agonist, promoting GLP-1 amide secretion
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However, in line with the specificity of CPA, the C-terminal residues of the L585I, L585M, and L585V variants were cleaved in vitro upon exposure to the enzyme for 5 hours at 37 C, as confirmed by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis of the C-terminal peptides (Supplementary Table 1)
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= Biochimie Biol
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