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7-9 GLP-1 signaling has been shown to promote microglia-mediated expression of neurotrophic factors, such as brain-derived neurotrophic factor and nerve growth factor, to promote neuronal survival and inhibit stress pathways in neurodegenerative conditions

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Importantly, the absence of large, controlled human studies means there is no reliable, standardized "before and after" schedule, only anecdotal reports

This cognitive shift represents central nervous system effects as semaglutide modulates appetite centers in your hypothalamus