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In other research, hormone therapy with tirzepatide caused even more weight loss, suggesting a potential synergy when these treatments are combined
A 2023 review in the Journal of Clinical Endocrinology & Metabolism highlighted GLP-1 receptor agonists as promising adjunct therapies for women with PCOS and metabolic dysfunction, particularly when insulin resistance and obesity are present
GLP-1 receptor agonists have shown consistent benefit in PCOS: a 2022 meta-analysis in Human Reproduction Update (N=10 trials, 484 women) found that GLP-1 agonist therapy reduced fasting insulin by 1.98 mIU/L, total testosterone by 0.19 nmol/L, and improved menstrual regularity in 55% of participants [10]
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