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Seek urgent medical attention if you experience: Severe or persistent abdominal pain, particularly if it radiates to your back this may indicate pancreatitis or gallbladder disease, which have been associated with GLP-1 receptor agonist class medicines [16] [17] Persistent vomiting or an inability to keep fluids down, which may lead to dehydration Yellowing of the skin or eyes, or dark urine (possible signs of liver or gallbladder problems) Signs of a serious allergic reaction, such as facial swelling, difficulty breathing, or a widespread rash Contact your prescriber or trial team if: Hunger is severe, persistent, and significantly interfering with your ability to adhere to the treatment plan You are experiencing rapid or unexpected weight gain despite taking the medication as prescribed You notice symptoms that may suggest hypoglycaemia (low blood sugar), such as shakiness, sweating, confusion, or palpitations

Grtner R et al

These intricate connections between hormones produced by adipose tissue and obesity underscore crucial mechanisms by which obesity fosters inflammation, insulin resistance, and metabolic conditions like type 2 diabetes

Common side effects may include dizziness, tiredness, and a slow heartbeat

Moreover, hypoxic stress was found to lead to the proliferation and hypertrophy of gill epithelial cells in channel catfish [5], as well as the occurrence of gill filaments curl and engorgement in tilapia gill tissue [6]

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