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Figure 1 In line with these observations, weight loss has emerged not only as a supportive strategy but also as a disease-modifying intervention in PsA ( Preclinical studies further suggest that GLP-1RAs may modulate key cytokine pathways implicated in psoriatic disease, including NF-B, IL-6, IL17, and IL23, while small clinical studies have reported improvements in skin disease severity in PsO ( This narrative review summarizes the current clinical evidence on GLP-1RAs in PsO and PsA and discusses future research directions aimed at evaluating their potential role in intercepting PsA development and improving outcomes in patients with complex immunometabolic profiles

4.2 SGLT2 inhibitors in the central nervous system SGLT1 is localized in the pyramidal cells of the brain cortex, Purkinje cerebellum cells, hippocampus pyramidal, and granular cells (Pawlos et al., 2021)

& Perreault, S

CH, LA, MM, FC, and JE assisted with data interpretation

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Weight loss no longer feels like a dreaded chore. Grayson P