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If metformin at a maximum tolerated dose does not achieve the HbA1c target after 3 months, add a second oral agent (a sulfonylurea [SU], thiazolidinedione [TZD], dipeptidyl peptidase 4 [DPP-4] inhibitor, or sodium-glucose cotransporter-2 [SGLT2] inhibitor), a glucagon-like peptide-1 (GLP-1) receptor agonist, or a basal insulin ( TABLE 2 )
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Months 5 to 6: Most patients report the clearest visual changes in this window, with improvements in abdominal definition and overall leanness
Moreover, in vitro cell culture experiments have confirmed that the correlation between GLP-1RA and pancreatic cancer may be related to its ability to induce phenotypic transformation of pancreatic exocrine cells into pancreatic endocrine cells (80, 81)
Berberine (Berberis aristata bark powder) What it is: Berberine is a bioactive compound extracted from several plants, including Berberis aristata
The liver, which maintains the highest concentrations of glutathione in the body (5 to 10 mM), is the primary site of this detoxification activity
