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Extrinsically aged skin is characterised by deeper wrinkles, a leathery appearance, irregular pigmentation and extensive loss of elasticity [26, 27]

We defined regions of interest (ROIs) using brain atlases 60,61,62

T., Cupples, G., Ooi, E

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Incretin hormones, including glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal