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Elevated FGF-23 Is Associated with Left Ventricular Hypertrophy and Mortality FGF-23 is not only a phosphate-regulating hormone but is also linked to cardiovascular disease and death in CKD patients

There are also indications in studies that fiber supplementation can help manage conditions like irritable bowel syndrome (IBS)

The key is not going up in dose too quickly

Patients on concurrent antidepressants (SSRIs, SNRIs) require extra monitoring during the taper

The other half is bioavailability

Many patients report appetite reduction during treatment, with effects generally becoming more noticeable as the dose is gradually increased