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Glucagon exerts potent lipolytic and thermogenic effects by stimulating hepatic fatty acid oxidation and BAT activity, although its hyperglycemic potential necessitates co-activation with GLP-1 to ensure net euglycemia [54]

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In particular, we observed that the -1 subcluster expressed low levels of ARX , IRX2 , CRYBA2 , ALDH1A1 , and TM4SF4

A gastric US was performed two weeks later (three weeks since the last semaglutide application) which showed an empty gastric antrum

activation remains weeks 14

Participants also saw their fat-to-lean mass ratio drop from 0.93 to 0.70 , along with a reduction in waist circumference by 18.418.5 cm