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Heres a comparison to semaglutide showing that the novel compound leads to more weight loss (blue dots are semaglutide, red dots are the new compound, black dots are placebo, and the Y-axis is body weight): Hitting different receptors may also mean an impact on tolerability - one of the big issues with these medications in the real world
Berberine, on the other hand, mainly influences metabolism by activating AMPK, the bodys energy sensor
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