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Aging is, in many ways, a result of accumulated oxidative damage over time
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There were overall 66,807 participants treated with metformin plus a combination of second- and third-line therapies
Weeks 17 to 20 (2.4mg maintenance dose) The maintenance dose produces maximum therapeutic effect and maximum gastric emptying delay
The primary outcome measures clinical remission using mMS at 12 weeks, while secondary endpoints include endoscopic remission, clinical response, and safety parameters, with the study having started in December 2024 and estimated completion in June 2028 across 52 locations in the US and Europe
Bosch et al
